Slice shrimp in half, lengthwise. Season with the salt and pepper and toss to coat.
Melt ghee in a large skillet over medium high heat. Add the shrimp in a single layer and cook until just cooked through, 3 to 4 minutes, tossing halfway through.
Add the garlic, lime zest and chipotle hot sauce and toss until well combined and heated through, 1 to 2 more minutes.
Remove from heat and stir in the lime juice.
Serve in lettuce leaves and topped with cilantro, if desired and serve with extra lime wedges. Enjoy!